BRUKINSA - A Powerful Choice in R/R mzl

A BTK INHIBITOR THAT
CONTINUES TO DELIVER
DEEP AND SUSTAINED
RESPONSES IN R/R MZL1,2

BRUKINSA® (zanubrutinib) is indicated for the treatment 
of adult patients with relapsed or refractory marginal zone lymphoma (MZL) 
who have received at least one anti-CD20-based regimen.

This indication is approved under accelerated approval based on overall response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.

Deep and sustained responses

Powerful responses with brukinsa regardless of risk factor or MZL subtype1

Response rates
CT-Based
Magnolia
(Study 214)
56
%
orr
study 003
(MZL)
80
%
orr
Response rates
PET-Based
magnolia
(study 214)
67
%
orr

Median follow-up time was 15.7 months for MAGNOLIA (Study 214) and 35.2 months for Study 003.3

Median DOR has not yet been reached.1

The efficacy of BRUKINSA was assessed by IRC in 2 clinical trials that included a total of 88 adult patients with MZL who received at least 1 prior therapy. Study BGB-3111-214 MAGNOLIA (Study 214): N=68, Phase 2, open-label, multicenter, single-arm trial; PET scans were required for response assessment. Study BGB-3111-AU-003 (Study 003): N=20, Phase 1/2, open-label, multicenter, single-arm trial; PET scans were not required for response assessment and the majority of patients were assessed mostly using CT scans.

*Two patients in MAGNOLIA (Study 214, N=68) were not evaluable for efficacy due to central confirmation of MZL transformation to diffuse large B-cell lymphoma.

55 patients were assessed by PET scan, with the remainder assessed by CT scan.


CI=confidence interval; CT=computed tomography; DOR=duration of response; IRC=independent review committee; ORR=overall response rate; PET=positron emission tomography; R/R=relapsed/refractory.

Personalized patient support
dedicated to helping patients

A personalized and comprehensive support program designed
to help guide and assist patients, caregivers, and practices.

Simplifying
Access
Educating
Patients
Securing
Support

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BTK inhibition
 
Brukinsa Difference
Established
Safety Profile
Safety
Flexible
Dosing
Dosing