Complete BTK inhibition
Complete BTK inhibition

BRUKINSA

is a BTK inhibitor that was designed to completely block BTK.

is a BTK inhibitor that was designed to completely block BTK.

is a BTK inhibitor that was] designed to completely block BTK.

is a BTK inhibitor that was designed to completely block BTK.

Why is a BTK inhibitor important for mantle cell lymphoma (MCL) treatment?

    MCL is caused by rapid growth and spread of cancerous B cells.
  • Bruton's tyrosine kinase (BTK) is a protein that signals to cancerous B cells, helping them to grow and spread
  • Blocking BTK can help stop this signaling

Treatment that is complete and consistent.

How well does
BRUKINSA work?

In 2 clinical studies, 118 patients with MCL received BRUKINSA after at least 1 prior therapy. In both clinical studies,

In 2 clinical studies, 118 patients with MCL received BRUKINSA after at least 1 prior therapy. In both clinical studies,

 
84 %

responded to
treatment, known
as the overall
response rate

responded to
treatment, known
as the overall
response rate

nearly
80 %

continued to
respond for a
year or longer

The effectiveness of BRUKINSA may vary for different people.

The effectiveness of BRUKINSA may vary for different people.

What are the possible side effects of BRUKINSA?

BRUKINSA may cause serious side effects, including:

  • Bleeding problems (hemorrhage) that can be serious and may lead to death. Your risk of bleeding may increase if you are also taking a blood thinner medicine. Tell your healthcare provider if you have any signs or symptoms of bleeding, including:

    • blood in your stools or black stools (looks like tar)
    • pink or brown urine
    • unexpected bleeding, or bleeding that is severe or you cannot control
    • vomit blood or vomit that looks like coffee grounds
    • cough up blood or blood clots
    • increased bruising
    • dizziness
    • weakness
    • confusion
    • changes in your speech
    • headache that lasts a long time
  • Infections that can be seriousand may lead to death. Tell your healthcare provider right awayif you have fever, chills, or flu-like symptoms.
  • Decrease in blood cell counts. Decreased blood counts (white blood cells, platelets, and red blood cells) are common with BRUKINSA, but can also be severe. Your healthcare provider should do blood tests during treatment with BRUKINSA to check your blood counts.
  • Second primary cancers. New cancers have happened in people during treatment with BRUKINSA, including cancers of the skin. Use sun protection when you are outside in sunlight.
  • Heart rhythm problems (atrial fibrillation and atrial flutter). Tell your healthcare provider if you have any of the following signs or symptoms:

    • your heartbeat is fast or irregular
    • feel lightheaded or dizzy
    • pass out (faint)
    • shortness of breath
    • chest discomfort


What are the most common side effects?

The following side effects occurred in 20% or more of patients taking BRUKINSA:

  • Decreased white blood cells
  • Decreased platelet count
  • Rash
  • Diarrhea
  • Upper respiratory infection
  • Decreased red blood cells (anemia)
  • Bruising
  • Cough

What are the most common side effects?

The following side effects occurred in 20% or more of patients taking BRUKINSA:

  • Decreased white blood cells
  • Decreased platelet count
  • Rash
  • Diarrhea
  • Upper respiratory infection
  • Decreased red blood cells (anemia)
  • Bruising
  • Cough

7% of patients discontinued treatment due to side effects in the trials.

These are not all the possible side effects of BRUKINSA. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

7% of patients discontinued treatment due to side effects in the trials.

These are not all the possible side effects of BRUKINSA. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

How long will I be on treatment with BRUKINSA?

You will take BRUKINSA for as long as your doctor thinks it is helping you, or for as long as side effects are manageable.

About 18 months was the median duration of treatment for patients in the clinical studies. The median marks the midpoint where half of the patients were still taking BRUKINSA, while half were no longer on treatment.

Remember, everyone responds differently to treatment, so the length of time that you take BRUKINSA could be shorter or longer.

How long will I be on treatment with BRUKINSA?

You will take BRUKINSA for as long as your doctor thinks it is helping you, or for as long as side effects are manageable.

About 18 months was the median duration of treatment for patients in the clinical studies. The median marks the midpoint where half of the patients were still taking BRUKINSA, while half were no longer on treatment.

Remember, everyone responds differently to treatment, so the length of time that you take BRUKINSA could be shorter or longer.

myBeiGene

Patient Support Program

Call 1-833-BeiGene ( 1-833-234-4363) to talk with an Oncology Nurse Advocate or learn more here

myBeiGene

Patient Support Program

Call 1-833-BeiGene

(1-833-234-4363)

to talk with an

Oncology Nurse

Advocate or

learn more here